Considering the fact that timing attacks based on memcmp short circuiting were shown to be remotely practical a decade ago, latency isn't going to be an issue.

Considering the fact that timing attacks based on memcmp short circuiting were shown to be remotely practical a decade ago, latency isn't going to be an issue. The bigger question is whether you can get down your inputs to a small enough number to practically determine PRNG state (you probably can).