We will be able to do direct brain input in the future, much better than running around in a holodeck, so we will be able to fool the brain entirely. Alcohol is

We will be able to do direct brain input in the future, much better than running around in a holodeck, so we will be able to fool the brain entirely. Alcohol is not forbidden, just not permitted while on duty and not served on board ship. The problem with Bashir was that he was genetically enhanced to be superior. He wasn't just treated for a medical issue. The Maquis were renegade Federation not anti-Federation though, that seems hard to avoid, you can't please everyone. The Federation has no policy against succession and no walls to act as a prison. Anyone is free to come and go. You have access to all the resources needed to live. And it's not that no one ever commits a crime, just that it's exceptionally rare, not part of regular life.