I'd go with ASP.NET MVC. Probably one of the less common answers you'll get here, but I think if you choose one of the more popular and well-supported options (

I'd go with ASP.NET MVC. Probably one of the less common answers you'll get here, but I think if you choose one of the more popular and well-supported options (Rails, Django, ASP.NET MVC, Java) you won't really go wrong. Just check out each one and pick the one you feel has the best fit for your coding style. A properly-built site will separate the coding from the style, so it won't really matter what's underneath.