It's kind of the opposite of what you're talking about, but I'd recommend reading "Permutation City" by Greg Egan (if you haven't already). The main premise is

It's kind of the opposite of what you're talking about, but I'd recommend reading "Permutation City" by Greg Egan (if you haven't already). The main premise is that in the future, human mind uploading is possible, but there's some upper limit on computation that prevents the uploads from running at real time. Instead, they are simulated at something like a ratio of 17 to 1. The story explores concepts of isolation as a growing society of uploads becomes more and more detached from the causality of "reality." The real world isn't a place you can conveniently interact with when you run 17 times slower than everyone in it. Plus there are interesting segments about an uploaded person having himself simulated with greater and greater real time between each simulated timestep, and with "skipped frames" that are imperceptible to the one being simulated (e.g. counting from 1 to 10, where you have the memory of having said "9" and being about to say "10" but the "frame" where you said "9" was never actually simulated and it skipped ahead).