If you have a Mac and prefer a little GUI tool, Anvil is great: http://anvilformac.com http://anvilformac.com It has built-in support for .xip.io domains; you

If you have a Mac and prefer a little GUI tool, Anvil is great: http://anvilformac.com http://anvilformac.com It has built-in support for .xip.io domains; you can configure multiple sites by pointing it at local directories and it'll serve them up using a built-in POW server (http://pow.cx http://pow.cx, also from 37signals). Great for example for remote testing on your local LAN without having to mess with your HOSTS file.