3 ms·

Single gene that can boost IQ by 6 points discovered

7 points by feelthepain 12y ago

mrfusion 12y ago
If you're curious if you have this variant, I believe you can look at your 23andme data here: https://www.23andme.com/you/explorer/snp/?snp_name=rs9536314 https://www.23andme.com/you/explorer/snp/?snp_name=rs9536314 One 'G' means you have one copy, two 'G's means you have two copies. All 'T's means you don't have it. Read on for how I figured it out. I may have it wrong? Out of curiosity, I'm trying to figure out if my 23andme data would report this variant. I made some progress but I'm a bit confused what to look for once I find the gene. This talks about related SNP's? http://www.snpedia.com/index.php/KL http://www.snpedia.com/index.php/KL I think any 23andme data would be here? https://www.23andme.com/you/explorer/gene/?gene_name=KL https://www.23andme.com/you/explorer/gene/?gene_name=KL
- mrfusion 12y ago
  Here's some more information describing it: "A haplotype, "KL-VS", composed of six single nucleotide polymorphisms (SNPs), spans exon 2 and its flanking sequence. Two of these SNPs result in amino acid substitutions: F352V (rs9536314) and C370S (rs9527025). "KL-VS" refers to the V and S alleles of these SNPs respectively, and since all six SNPs occur in perfect linkage disequilibrium, a single variant, F352V, can be used to tag the haplotype [4]." from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534014/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534014/
  - mrfusion 12y ago
    Ok so for me, 23andme reports this: rs9536314 TT (https://www.23andme.com/you/explorer/snp/?snp_name=rs9536314 https://www.23andme.com/you/explorer/snp/?snp_name=rs9536314) But I'm not sure if T or G would correspond to the F352V variant? Anyone know who to find out?
    - mrfusion 12y ago
      Ok bummer, I think you want to have G to have this IQ boosting variant. F352V refers to a phenylalanine (F) to valine (V) substitution at aminoacid position 352. [1] And according to this codon table [2], GTT produces Valine while TTT produces phenylalanine. Well at least I learned something... [1] http://www.ncbi.nlm.nih.gov/pubmed/16955217 http://www.ncbi.nlm.nih.gov/pubmed/16955217 [2] http://en.wikipedia.org/wiki/DNA_codon_table http://en.wikipedia.org/wiki/DNA_codon_table

7 points by feelthepain 12y ago

If you're curious if you have this variant, I believe you can look at your 23andme data here: https://www.23andme.com/you/explorer/snp/?snp_name=rs9536314 https://www.23andme.com/you/explorer/snp/?snp_name=rs9536314 One 'G' means you have one copy, two 'G's means you have two copies. All 'T's means you don't have it. Read on for how I figured it out. I may have it wrong? Out of curiosity, I'm trying to figure out if my 23andme data would report this variant. I made some progress but I'm a bit confused what to look for once I find the gene. This talks about related SNP's? http://www.snpedia.com/index.php/KL http://www.snpedia.com/index.php/KL I think any 23andme data would be here? https://www.23andme.com/you/explorer/gene/?gene_name=KL https://www.23andme.com/you/explorer/gene/?gene_name=KL

mrfusion 12y ago
Here's some more information describing it: "A haplotype, "KL-VS", composed of six single nucleotide polymorphisms (SNPs), spans exon 2 and its flanking sequence. Two of these SNPs result in amino acid substitutions: F352V (rs9536314) and C370S (rs9527025). "KL-VS" refers to the V and S alleles of these SNPs respectively, and since all six SNPs occur in perfect linkage disequilibrium, a single variant, F352V, can be used to tag the haplotype [4]." from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534014/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1534014/
- mrfusion 12y ago
  Ok so for me, 23andme reports this: rs9536314 TT (https://www.23andme.com/you/explorer/snp/?snp_name=rs9536314 https://www.23andme.com/you/explorer/snp/?snp_name=rs9536314) But I'm not sure if T or G would correspond to the F352V variant? Anyone know who to find out?
  - mrfusion 12y ago
    Ok bummer, I think you want to have G to have this IQ boosting variant. F352V refers to a phenylalanine (F) to valine (V) substitution at aminoacid position 352. [1] And according to this codon table [2], GTT produces Valine while TTT produces phenylalanine. Well at least I learned something... [1] http://www.ncbi.nlm.nih.gov/pubmed/16955217 http://www.ncbi.nlm.nih.gov/pubmed/16955217 [2] http://en.wikipedia.org/wiki/DNA_codon_table http://en.wikipedia.org/wiki/DNA_codon_table