> the worst case is that the antibiotic period breeds superbugs that are both more virulent and harder to kill than those that came before. If anything, antibi

> the worst case is that the antibiotic period breeds superbugs that are both more virulent and harder to kill than those that came before. If anything, antibiotic-resistant strains of bacteria would generally be less fit in a world without antibiotics. E.g., sulfa drugs inhibit DHPS which is involved in producing what eventually becomes formic acid. Bacteria can resist sulfonamides by eliminating their dependence on DHPS, but then they depend on folic acid being present in their environment, and it won't always be available in human blood.