So that's the downside: the Big VC will make a Series A harder if they are the first to reject you when shopping for that Series A. Solution: don't approach th

So that's the downside: the Big VC will make a Series A harder if they are the first to reject you when shopping for that Series A. Solution: don't approach the seed VC for a follow-on, skip it or postpone it until last resort, in which case the new alternatives can used as 'Stalking Horses' on the seed VC anyway if playing hardball. Big VC seed money is a good endorsement and help for a company, and the upside is the chance of an easy follow-on from them because they have the pockets: but wait for them to come calling first, or have some Stalking Horses ready if you sense being played. Otherwise just skip them altogether on a Series A.