It depends on what you're going after, but if you're just targeting a local subnet, that's what a "man-in-the-middle" attack is for. What is probably easier is

It depends on what you're going after, but if you're just targeting a local subnet, that's what a "man-in-the-middle" attack is for. What is probably easier is somehow redirecting the DNS entry for the target site to point to your malware-serving site, which has happened before as well.