1. There are some people who claim to make whole-brain simulations based on earlier anatomical data [1,2]. I don't expect that anyone can make meaningful predic

1. There are some people who claim to make whole-brain simulations based on earlier anatomical data [1,2]. I don't expect that anyone can make meaningful predictions by simulating the new map, because the neuronal models used are either rudimentary, or do not capture neuronal variability (also non-neuron cells may be involved). However, the analysis of the connectivity between various regions as well as intra-region may lead to accurate predictions about what many circuits "do". 2. Functional imaging is advancing, but it's still very hard to capture large-scale neuronal activity. The current state of the art, calcium imaging can visualize activity from one focal plane, not too many neurons at a time, with slow time resolution, and only at the surface. I 'd say we are pretty far from that as it would require some amazing imaging technology. 1. http://www.izhikevich.org/publications/large-scale_model_of_human_brain.htm http://www.izhikevich.org/publications/large-scale_model_of_... 2. http://bluebrain.epfl.ch/ http://bluebrain.epfl.ch/