Agreed that cloud services may be using OpenSSL to transfer the KeePass database to/from the client. Presume an attacker obtains the KeePass database via a MITM

Agreed that cloud services may be using OpenSSL to transfer the KeePass database to/from the client. Presume an attacker obtains the KeePass database via a MITM attack on communications to/from this cloud service. Then what? The attacker needs to penetrate the defenses of the KeePass database itself, so I'm unsure of the point you're trying to make with KeePass and cloud services.