For the biologically inclined, I sincerely recommend reading this paper in full. It has a number of extremely groundbreaking hypothesis, which bring together th

For the biologically inclined, I sincerely recommend reading this paper in full. It has a number of extremely groundbreaking hypothesis, which bring together the common elements of cancer, caloric restriction, and aging. I find it interesting that this finding suggests that free radical/reactive-oxygen-species theories of aging were close, but just off the mark. It appears that the cell can cope quite well with chemical damage of this type, but has a harder time regulating mtDNA expression, which leads to the same result: reduced mitochondria function with age.