> I've heard of doctors prescribing drug holidays to > minimize tolerance (and also heard this was no longer current > practice from an expert in the fiel

> I've heard of doctors prescribing drug holidays to > minimize tolerance (and also heard this was no longer current > practice from an expert in the field). When you say "drug holiday" do you mean temporarily reducing your dosage, or temporarily stopping the medication entirely? I can't speak for current practice in general, but I've had a couple of doctors and a nurse practitioner recommend tapering down my dose a bit on days when it's possible (ie, days off from work, etc) in the last few years. I don't know if everybody would respond this way, but a lot of feel doing that helps stop tolerance/dosage creep, which was definitely a thing I experienced in the beginning. After some experimentation it seems like the way to go for me. I've been steady at a prescription of 15mg/day for a few years. Some days I take ~10mg and some days I take ~20mg.