For a lot of businesses isn't it a realistic option to just ignore the state governments? If the IRS says "jump" you say "how high?" But if the state of Pennsyl

For a lot of businesses isn't it a realistic option to just ignore the state governments? If the IRS says "jump" you say "how high?" But if the state of Pennsylvania starts complaining and you don't have a presence in that state, what the heck can they really do about it?