The noise factor can be remedied with clever tweaking of the Cas9 protein, as mentioned in the article. This research is currently underway. The key is, optimi

The noise factor can be remedied with clever tweaking of the Cas9 protein, as mentioned in the article. This research is currently underway. The key is, optimizing the Cas9 protein is much easier than optimizing an infinite number of designer proteins targeting individual sequences, which is what previous methods required.