If you use a native click-to-play solution, it will prevent it unless you're victim of some kind of clickjacking attack. If you use a show-then-hide-with-CSS s

If you use a native click-to-play solution, it will prevent it unless you're victim of some kind of clickjacking attack. If you use a show-then-hide-with-CSS script (there are several for Chrome, for example), they won't prevent it.