I don't know anything about Wellbutrin in particular, so it's entirely possible that its effects are very different from what I'm aware of and that it won't fit

I don't know anything about Wellbutrin in particular, so it's entirely possible that its effects are very different from what I'm aware of and that it won't fit this pattern, but in my experience it is always important that people who are just starting anti-depressants or are switching anti-depressants have extra support and people looking out for them during the transition period; this isn't because anti-depressants don't work, it's because they take time to gain full effectiveness. A typical pattern is that patients will start to feel empowered and motivated to do something about their situation before they start to feel happy- as a result, "doing something about their situation" frequently means "trying to end it through suicide". The medication is working just fine, it's just not up to full effectiveness, and needs to be given time to get the patient through the transition period to where they stop wanting to kill themselves. (Source: several friends with clinical depression who have gone through this, plus a wife who recently completed a semester working as a psychiatric student nurse.)