4 ms·
Heart disease etc, including[1]: "This is why hemoglobin A1C is frequently used in studies that try to correlate blood sugar control to various disease process
by CEyzaguirre 13y ago
Heart disease etc, including[1]:
"This is why hemoglobin A1C is frequently used in studies that try to correlate blood sugar control to various disease processes like Alzheimer’s, mild cognitive impairment, and coronary artery disease.
It’s well documented that glycated hemoglobin is a powerful risk factor for diabetes, but it’s also been correlated with risk for stroke, coronary heart disease, and death from other illnesses. These correlations have been shown to be strongest with any measurement of hemoglobin A1C above 6.0 percent.
We now have evidence to show that elevated hemoglobin A1C is associated with changes in brain size. In one particularly profound study, published in the journal Neurology, researchers looking at MRIs to determine which lab test correlated best with brain atrophy found that the hemoglobin A1C demonstrated the most powerful relationship.[2]”
[1] Perlmutter, David. “Grain Brain.”
[2] “C. Enzinger, et al., “Risk Factors for Progression of Brain Atrophy in Aging: Six-year Follow-up of Normal Subjects,” Neurology 64, no. 10 (May 24, 2005): 1704–11.”
- carbocation 13y agoNondiabetics have normal A1c because they do not exhibit wild blood glucose swings, even postprandially.
- snowwrestler 13y agoBlood sugar levels are not a reliable proxy for dietary sugar intake.
- eclipxe 13y agoTell that to diabetics
- snowwrestler 13y agoDiabetics know better than anyone that dietary sugar is not the only food that can increase blood sugar. Rice cakes have no sugar in them at all, for instance, but have a higher glycemic index than chocolate cake.
- eclipxe 13y agoDietary sugar intact/dietary carb intake - at the end of the day, it turns into sugar
- snowwrestler 13y agoBut that's not what the article is about. It a about dietary sugar--sucrose and fructose specifically.
- mamoswined 13y agoPerlmutter's stuff is way out of the left field. If you read the actual study, it does not support his conclusions. Interestingly, there are studies that show that a vegan grain-rich diet lowers hemoglobin A1C. So much for his made-up "grain brain" condition. Of course most diets studied lower it, because they are much healthier than the standard american diet of overeating. And it's also perfectly possible to be a moderate consumer of sugar and have low hemoglobin A1C depending on other lifestyle factors.