Thanks for the question! PLGA is the one of the most commonly implanted biodegradable materials in the world - primarily because it is used is used in dissolvi

Thanks for the question! PLGA is the one of the most commonly implanted biodegradable materials in the world - primarily because it is used is used in dissolving suture (check out this link to very popular PLGA based suture material). Aston S, Rees T. Vicryl Sutures. Aesthetic Plastic Surgery 1977;1:5. The "threatening point" is just a way of describing what TLR-4 (MPLA) and TLR-9 (CpG) do. In particular, MPLA "looks like" bacterial cell wall and CpG "looks like" bacterial DNA to the immune system. Steinhagen F. TLR-based immune adjuvants. Vaccine, 2011: 12. We did not consider using nano spheres because we wanted to get as much payload as possible into the antigen presenting cells without requiring multiple phagocytosis events per cell.