3 ms·
Is there more basic research supporting this interaction (crystallographic or otherwise) between the peptide and T cell? The paper feels like to jumps right int
by kayhi 13y ago
Is there more basic research supporting this interaction (crystallographic or otherwise) between the peptide and T cell? The paper feels like to jumps right into animal models.
"specific points identified by a data-driven analysis of actual individuals’ immune systems" pg1
What is the data in this case?
What is the sequence of the peptide(s) that are incorporated into the PLGA?
Side note: our start up works on helping biotech companies source reagents, supplies and equipment, we should be able to save you about ~15% on the ~475k part of the budget
- naveenspark 13y agoNaveen here from Immunity Project. Thanks for the question. We have not done receptor analysis. We are using animal models as our starting point - we are looking for an immune response with memory to the administered peptides - if we get that response in Phase I we should be in good shape! We received the peptides from researchers who have a manuscript in publication and would like us to keep the sequences confidential until they publish. Please see below for similar statistical research looking for targets to beneficial regions on HIV: Mothe B, Anuska L, Ibarrondo J, Daniels M, Miranda C, Zamarreno J, et al. Definition of the viral targets of protective HIV-1-specific T cell responses. Journal of Translational Medicine 2011;9(208):20. re: your startup / cost savings on reagents, supplies and equipment, we would love to talk to you about that. Please email us at team@immunityproject.org. Thanks!