3 ms·

> double (triple?) blind study of mice Would that be a study where the mice are not aware of if they are in the control or not? Has the placebo effect been se

by Crito 13y ago

> double (triple?) blind study of mice Would that be a study where the mice are not aware of if they are in the control or not? Has the placebo effect been seen in mice?

jmmcd 13y ago
You've never heard of the three blind mice? I believe the farmer's wife won a Nobel prize for her work in regeneration of severed limbs.
- Crito 13y ago
  I'm a little ashamed to admit that you had me googling for that. ;) Seriously though, the idea that mice might have a placebo effect is fascinating. I would have thought that the placebo effect would require some high-level form of self-awareness (which perhaps mice do have, I don't really know) and an understanding of at least the purpose of medicine. Maybe not though...
  - yaddayadda 13y ago
    Mice are the most intelligent species on Earth. In fact, they are so smart that they are immune to placebo effects. However, they act like they aren't because our reactions provide them much entertainment - http://hitchhikers.wikia.com/wiki/Mice http://hitchhikers.wikia.com/wiki/Mice Edited to add: On a more serious note, I don't know if mice are susceptible to a Hawthorne-like effect http://psychology.about.com/od/hindex/g/def_hawthorn.htm http://psychology.about.com/od/hindex/g/def_hawthorn.htm Even physical science researchers have to deal with observer effects http://en.wikipedia.org/wiki/Observer_effect_%28physics%29 http://en.wikipedia.org/wiki/Observer_effect_%28physics%29 Edited to clean up brain-drained errors.
saalweachter 13y ago
I don't know what you or the OP are thinking of, but it's worth pointing out that the placebo effect is not just a phenomenon in the patients' minds; it can also be a phenomenon in doctors' minds. In brief, any time you have a subjective measurement (for instance, the experimenter assigns a number from 1 to 5 based on how "distressed" the mice -- or human patients -- look), that subjective measurement can be subtly biased. So if the experimenter doesn't blind his experiments properly, you can see a placebo effect in animal studies. It is appropriate to refer to these studies as double or triple blind because the single blind usually refers to the patient. Single blind: patients do not know which group they are in Double blind: experimenters do not know the group identities Triple blind: overseeing committees do not know the group identities So animal studies can be assumed to be single blind by default, and become double-blind when the experimenters do not know the group identities.
- Crito 13y ago
  My understanding is that the "placebo effect" doesn't refer to biased numbers or reporting, but exists when everything is measured correctly. It is objectively there, not a screwy result.
  - yaddayadda 13y ago
    You're correct. What saalweachter was describing are ways to minimize threats to reliability and validity. - http://www.socialresearchmethods.net/kb/relandval.php http://www.socialresearchmethods.net/kb/relandval.php - http://www.mathcs.duq.edu/~packer/Courses/Psy624/Validity.html http://www.mathcs.duq.edu/~packer/Courses/Psy624/Validity.ht... - https://en.wikipedia.org/wiki/Internal_validity https://en.wikipedia.org/wiki/Internal_validity - https://en.wikipedia.org/wiki/External_validity https://en.wikipedia.org/wiki/External_validity
  - saalweachter 13y ago
    "Biased" is probably a loaded word. I think I may have implied intent without meaning to. But basically, the placebo effect only exists for subjective measurements. (http://en.wikipedia.org/wiki/Placebo#Mechanism_of_the_effect http://en.wikipedia.org/wiki/Placebo#Mechanism_of_the_effect) If something exists only in subjective measurements and not objective measurements... I'll let you draw your own inference.

by Crito 13y ago

> double (triple?) blind study of mice Would that be a study where the mice are not aware of if they are in the control or not? Has the placebo effect been seen in mice?

jmmcd 13y ago

You've never heard of the three blind mice? I believe the farmer's wife won a Nobel prize for her work in regeneration of severed limbs.

Crito 13y ago
I'm a little ashamed to admit that you had me googling for that. ;) Seriously though, the idea that mice might have a placebo effect is fascinating. I would have thought that the placebo effect would require some high-level form of self-awareness (which perhaps mice do have, I don't really know) and an understanding of at least the purpose of medicine. Maybe not though...
- yaddayadda 13y ago
  Mice are the most intelligent species on Earth. In fact, they are so smart that they are immune to placebo effects. However, they act like they aren't because our reactions provide them much entertainment - http://hitchhikers.wikia.com/wiki/Mice http://hitchhikers.wikia.com/wiki/Mice Edited to add: On a more serious note, I don't know if mice are susceptible to a Hawthorne-like effect http://psychology.about.com/od/hindex/g/def_hawthorn.htm http://psychology.about.com/od/hindex/g/def_hawthorn.htm Even physical science researchers have to deal with observer effects http://en.wikipedia.org/wiki/Observer_effect_%28physics%29 http://en.wikipedia.org/wiki/Observer_effect_%28physics%29 Edited to clean up brain-drained errors.

saalweachter 13y ago

I don't know what you or the OP are thinking of, but it's worth pointing out that the placebo effect is not just a phenomenon in the patients' minds; it can also be a phenomenon in doctors' minds. In brief, any time you have a subjective measurement (for instance, the experimenter assigns a number from 1 to 5 based on how "distressed" the mice -- or human patients -- look), that subjective measurement can be subtly biased. So if the experimenter doesn't blind his experiments properly, you can see a placebo effect in animal studies. It is appropriate to refer to these studies as double or triple blind because the single blind usually refers to the patient. Single blind: patients do not know which group they are in Double blind: experimenters do not know the group identities Triple blind: overseeing committees do not know the group identities So animal studies can be assumed to be single blind by default, and become double-blind when the experimenters do not know the group identities.

Crito 13y ago
My understanding is that the "placebo effect" doesn't refer to biased numbers or reporting, but exists when everything is measured correctly. It is objectively there, not a screwy result.
- yaddayadda 13y ago
  You're correct. What saalweachter was describing are ways to minimize threats to reliability and validity. - http://www.socialresearchmethods.net/kb/relandval.php http://www.socialresearchmethods.net/kb/relandval.php - http://www.mathcs.duq.edu/~packer/Courses/Psy624/Validity.html http://www.mathcs.duq.edu/~packer/Courses/Psy624/Validity.ht... - https://en.wikipedia.org/wiki/Internal_validity https://en.wikipedia.org/wiki/Internal_validity - https://en.wikipedia.org/wiki/External_validity https://en.wikipedia.org/wiki/External_validity
- saalweachter 13y ago
  "Biased" is probably a loaded word. I think I may have implied intent without meaning to. But basically, the placebo effect only exists for subjective measurements. (http://en.wikipedia.org/wiki/Placebo#Mechanism_of_the_effect http://en.wikipedia.org/wiki/Placebo#Mechanism_of_the_effect) If something exists only in subjective measurements and not objective measurements... I'll let you draw your own inference.