Well, I don't think the choice of framework matters for a large project. What matters is the language, and both use python. Frameworks are only starting point.

Well, I don't think the choice of framework matters for a large project. What matters is the language, and both use python. Frameworks are only starting point. When you build a large software, there would be many things that framework cannot cover up. No matter how frameworks organize parts of a large software, it's not enough. You should organize by python way, not by django way or flask way. Django app concept? It's good, but what if a single app grows too big? Split two apps? Then what if a project has hundreds apps? We should break down with python modules and packages for a large software. Flask is simple, and it's good for beginners. But is the simplicity helpful for a long-term project? It saves only learning curve of first week. Django supports many features and that's also good, but it only saves time to develop the features. Because flask already supports a lot, the saved time would not be much for a long-term project. Django or Flask matters only for small projects, such as one month long. The choice doesn't matter for a large project. Yes, django template sucks, but you can change to mako or jinja or something else. You like django ORM? That's a good news, but even if you don't like it, you can use SQLAlchemy in django. Such changes can be wastes of time for short-term project, but no problem for large projects. Code pythonic. That's the answer.