+1 Flask, especially if you already have experience with it. Check out this Flask boilerplate: https://github.com/imwilsonxu/fbone https://github.com/imwilsonx

+1 Flask, especially if you already have experience with it. Check out this Flask boilerplate: https://github.com/imwilsonxu/fbone https://github.com/imwilsonxu/fbone It has Flask-login, sqlalchemy, wtforms, and other key extensions all configured out of the box. I don't have the most extensive experience but from what I understand, this template app incorporates a lot of the best practices for large scale applications.