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The hazard here is not inside a fully parallel blinded trial with controls in the same environment, but in comparison and replication of studies, as well as seq
by mapt 13y ago
The hazard here is not inside a fully parallel blinded trial with controls in the same environment, but in comparison and replication of studies, as well as sequential studies where the lab temperature changed. If quite minor, to human senses, changes in temperature significantly affect tumor formation, then up until now that's been a huge noise source in cross-study comparison, and temperature should be at least recorded precisely over time for all future tox studies.
- tehwalrus 13y agonot necessarily so - the article mentions that the cold inhibits two specific immune cell types; discovered drugs may only be effective in combating tumors arising from these specific deficits, which aren't relevant in real scenarios, i.e. a systematic error from cold in all studies.