Beta-lactamases are now pretty much everywhere, but the difference with NDM-1 is that it's not inhibited by the standard defence against beta-lactamases, clavul

Beta-lactamases are now pretty much everywhere, but the difference with NDM-1 is that it's not inhibited by the standard defence against beta-lactamases, clavulanic acid. With these plasmid being traded around out in the wild, the fear is that we might soon see all beta-lactams become useless, like penicillin is now.