5 ms·

The ends of your chromosomes are sensitive to a variety of environmental factors

41 points by shawndumas 13y ago

tannerc 13y ago
After working in an agency setting while trying to run several small projects on the side, I can see why work-related stress would turn hair white and bring about countless wrinkles prematurely. With that said, alcohol may help to a degree, but with the stressors of everyday life it's too easy to get carried away. For awhile I was drinking nearly every night of the week. I would drink in an attempt to forget about the failures of my career and the debts I had taken on as a result. Only to find that those worries were still very realistically there the next day, and I had lost time that would otherwise have been spent working or improving myself, thanks to drinking. Now, due in-part to meditation, a closer circle of friends and peer supporters, and a lot of reading, I haven't touched more than a single beer in two weeks. And it feels great because it allows me to get more done.
- j_s 13y ago
  Congratulations on this change!
tarice 13y ago
Noting that the experiments described in the article were performed on yeast, can anybody better versed in biology convey a better idea on how applicable to humans these results are? As described in the article, we both have telomeres, but as far as I know the comparison ends there.
- sp332 13y ago
  Other research has already found an association between caffeine intake and lower incidence of cancer in humans. http://www.cancerletters.info/article/S0304-3835%2808%2900667-8/abstract http://www.cancerletters.info/article/S0304-3835%2808%290066... So the research doesn't seem to transfer at all.
  - CanSpice 13y ago
    Well, this article states that caffeine shortens telomeres, and shortened telomeres are a hallmark of aging. Lengthened telomeres are associated with cancers. This seems to imply that the research done in this article (on yeast) correlates with the research you linked.
- VLM 13y ago
  As a guy who's done some homebrewing, yeast can handle alcohol concentrations which if placed in a mammal bloodstream would result in instant death. Its a matter of about 1.5 orders of magnitude not a minor difference. That has certain implications for what their cellular insides can tolerate vs ours. So something in the cellular structure of yeasts "shields their innards" a lot better than cells in our body. A moderate booze fest to the deep innards of a yeast cell might for a mammal cell be achieved by merely sniffing an open beer bottle. It would require further research. Its a particularly bad combo, using yeasts and alcohols to extrapolate to humans. Like "randomly" selecting a halophile to extrapolate human salt tolerance, or "randomly" selecting a thermophile to extrapolate human temperature tolerance. I see no similar obvious reason not to extrapolate caffeine/yeast combo to humans other than the usual multi-cellular vs unicellular issues.
- ansible 13y ago
  Noting that the experiments described in the article were performed on yeast, can anybody better versed in biology convey a better idea on how applicable to humans these results are? Yes, I'd like to know too. Which, if any of these genes that regulate telomere length are also present in humans?
SheepSlapper 13y ago
As someone who's addicted to both, I can't really tell if this revelation is good, bad, or otherwise.
- myth_drannon 13y ago
  Just drink Irish coffee and one will cancel the other's effects.
DigitalJack 13y ago
Meditation is seemingly helpful wrt telomerase. http://www.academia.edu/4326346/The_link_between_mindfulness_self-compassion_and_telomerase_activity_in_psoriasis_Results_from_a_controlled_MBCT_trial http://www.academia.edu/4326346/The_link_between_mindfulness...
- VLM 13y ago
  I looked at the study and everyone involved smoked and drank to some extent, and the meditation had some improvement on depression/anxiety/worry all of which are usually blamed for cig / booze use. At least some subjects were likely self medicating themselves and its highly likely the semi-dramatic change in reported attitude would lead to semi-dramatic change in self medication. However booze/cigs use after the experiment was not charted which is highly unfortunate. It seems highly likely meditation reduces self-medication due to improved mental state, and reduced self medication as per this article study has some direct effect on telomerase. So indirectly it sounds like a believable testable falsifiable hypothesis but its hardly been proven.
  - DigitalJack 13y ago
    I may have found the wrong study. I know of a few so I'll go back and see if the others were better. Edit: better study http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057175/#S29title http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057175/#S29titl...
bobchops 13y ago
The article is misleading. Longer telomeres don't mean longer life. Telomeres in mice are 4 times as long as those found in humans and they are particularly susceptible to damage from oxidative stress.
rsgalloway 13y ago
FTA: "and alcohol (and acetic acid) lengthen [telomeres]." funny, these findings seem to contradict this study: "Shortened telomeres in individuals with abuse in alcohol consumption" http://www.ncbi.nlm.nih.gov/pubmed/21351086 http://www.ncbi.nlm.nih.gov/pubmed/21351086

41 points by shawndumas 13y ago

After working in an agency setting while trying to run several small projects on the side, I can see why work-related stress would turn hair white and bring about countless wrinkles prematurely. With that said, alcohol may help to a degree, but with the stressors of everyday life it's too easy to get carried away. For awhile I was drinking nearly every night of the week. I would drink in an attempt to forget about the failures of my career and the debts I had taken on as a result. Only to find that those worries were still very realistically there the next day, and I had lost time that would otherwise have been spent working or improving myself, thanks to drinking. Now, due in-part to meditation, a closer circle of friends and peer supporters, and a lot of reading, I haven't touched more than a single beer in two weeks. And it feels great because it allows me to get more done.

j_s 13y ago
Congratulations on this change!

tarice 13y ago

Noting that the experiments described in the article were performed on yeast, can anybody better versed in biology convey a better idea on how applicable to humans these results are? As described in the article, we both have telomeres, but as far as I know the comparison ends there.

sp332 13y ago
Other research has already found an association between caffeine intake and lower incidence of cancer in humans. http://www.cancerletters.info/article/S0304-3835%2808%2900667-8/abstract http://www.cancerletters.info/article/S0304-3835%2808%290066... So the research doesn't seem to transfer at all.
- CanSpice 13y ago
  Well, this article states that caffeine shortens telomeres, and shortened telomeres are a hallmark of aging. Lengthened telomeres are associated with cancers. This seems to imply that the research done in this article (on yeast) correlates with the research you linked.
VLM 13y ago
As a guy who's done some homebrewing, yeast can handle alcohol concentrations which if placed in a mammal bloodstream would result in instant death. Its a matter of about 1.5 orders of magnitude not a minor difference. That has certain implications for what their cellular insides can tolerate vs ours. So something in the cellular structure of yeasts "shields their innards" a lot better than cells in our body. A moderate booze fest to the deep innards of a yeast cell might for a mammal cell be achieved by merely sniffing an open beer bottle. It would require further research. Its a particularly bad combo, using yeasts and alcohols to extrapolate to humans. Like "randomly" selecting a halophile to extrapolate human salt tolerance, or "randomly" selecting a thermophile to extrapolate human temperature tolerance. I see no similar obvious reason not to extrapolate caffeine/yeast combo to humans other than the usual multi-cellular vs unicellular issues.
ansible 13y ago
Noting that the experiments described in the article were performed on yeast, can anybody better versed in biology convey a better idea on how applicable to humans these results are? Yes, I'd like to know too. Which, if any of these genes that regulate telomere length are also present in humans?

SheepSlapper 13y ago

As someone who's addicted to both, I can't really tell if this revelation is good, bad, or otherwise.

myth_drannon 13y ago
Just drink Irish coffee and one will cancel the other's effects.

DigitalJack 13y ago

Meditation is seemingly helpful wrt telomerase. http://www.academia.edu/4326346/The_link_between_mindfulness_self-compassion_and_telomerase_activity_in_psoriasis_Results_from_a_controlled_MBCT_trial http://www.academia.edu/4326346/The_link_between_mindfulness...

VLM 13y ago
I looked at the study and everyone involved smoked and drank to some extent, and the meditation had some improvement on depression/anxiety/worry all of which are usually blamed for cig / booze use. At least some subjects were likely self medicating themselves and its highly likely the semi-dramatic change in reported attitude would lead to semi-dramatic change in self medication. However booze/cigs use after the experiment was not charted which is highly unfortunate. It seems highly likely meditation reduces self-medication due to improved mental state, and reduced self medication as per this article study has some direct effect on telomerase. So indirectly it sounds like a believable testable falsifiable hypothesis but its hardly been proven.
- DigitalJack 13y ago
  I may have found the wrong study. I know of a few so I'll go back and see if the others were better. Edit: better study http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057175/#S29title http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057175/#S29titl...

bobchops 13y ago

The article is misleading. Longer telomeres don't mean longer life. Telomeres in mice are 4 times as long as those found in humans and they are particularly susceptible to damage from oxidative stress.

rsgalloway 13y ago

FTA: "and alcohol (and acetic acid) lengthen [telomeres]." funny, these findings seem to contradict this study: "Shortened telomeres in individuals with abuse in alcohol consumption" http://www.ncbi.nlm.nih.gov/pubmed/21351086 http://www.ncbi.nlm.nih.gov/pubmed/21351086