I'd be more worried about someone taking a known sequence like modified HN51 or smallpox as the payload. Next, combining it with effective malware that targets

I'd be more worried about someone taking a known sequence like modified HN51 or smallpox as the payload. Next, combining it with effective malware that targets FASTA files. One of those "incautious scientists" thinks they are synthesizing something benign, not taking precautions, and a highly infectious disease pops out.