Fig 1E seems promising, as it shows that the bound bases tend to be more conserved. That said, you are right that as far I could tell there were no direct meas

Fig 1E seems promising, as it shows that the bound bases tend to be more conserved. That said, you are right that as far I could tell there were no direct measurements of transcriptional effects. Either way, it was a good read, and brought up a bunch of interesting questions to figure out next.