3 ms·
Agreed. It's an interesting trend. I also just skimmed over it; however, I wonder how significant is their initial TF binding occupancy data. There are a bunch
by daemonk 13y ago
Agreed. It's an interesting trend. I also just skimmed over it; however, I wonder how significant is their initial TF binding occupancy data. There are a bunch of papers recently that looked at binding sites and found that they don't really correlate well with transcription. The cell is just a stochastic bag of molecules. TFs bind whereever they can. I wonder if they are just seeing noise.
- skosuri 13y agoFig 1E seems promising, as it shows that the bound bases tend to be more conserved. That said, you are right that as far I could tell there were no direct measurements of transcriptional effects. Either way, it was a good read, and brought up a bunch of interesting questions to figure out next.
- Estragon 13y agoYes, so much bullshit has been published over the last decade as a result of artifacts in the measurement of TFBS that you have to be skeptical.