My first thought on seeing the headline was, "What? Only 2?" Off the top of my head I can think of: 1. Amino acid coding 2. Transcription factor binding and t

My first thought on seeing the headline was, "What? Only 2?" Off the top of my head I can think of: 1. Amino acid coding 2. Transcription factor binding and transcriptional regulation 3. Post-transcriptional regulation and RNA degradation 4. Intron/Exon Splice sites 5. Chromosome structure and methylation 6. Origins of replication All of these have been shown to be controlled at least in part by the DNA's sequence. This story seems to be about a (very interesting) new wrinkle in (2) above.