Your link lost me at the first sentence. But the word "phenotype" reminded me of this 11 minute Khan Academy video. Maybe I'm just repeating the same thing. But

Your link lost me at the first sentence. But the word "phenotype" reminded me of this 11 minute Khan Academy video. Maybe I'm just repeating the same thing. But I thought Sal's video was worth sharing and easily digestible. https://www.khanacademy.org/science/healthcare-and-medicine/healthcare-misc/v/systemic-thinking-about-cancer https://www.khanacademy.org/science/healthcare-and-medicine/... tl;dr For whatever reason, Breast Cancer prefers to metastasize bone (which is a phenotype). Something as simple as giving cured Breast Cancer victims a calcium supplement can significantly reduce remission. Phenotypes >= Genotypes? Scientific article cited in comment section: http://www.nejm.org/doi/full/10.1056/NEJMoa0806285 http://www.nejm.org/doi/full/10.1056/NEJMoa0806285