3 ms·
At over 4000mg in humans in a 24 hour period and you overload the first two metabolic pathways in the liver for Acetaminophen, forcing it to go through another
by malandrew 13y ago
At over 4000mg in humans in a 24 hour period and you overload the first two metabolic pathways in the liver for Acetaminophen, forcing it to go through another pathway where a toxic by-product is made by the body.
Ingestion of alcohol can drop this approximate 4000mg before toxicity is experienced down to about 2000mg.
I know this because I've been skating awfully close to that 4000mg ceiling for about one week now. I had my tonsils removed last Wednesday and need at least 20mg of oxycodone per 4-6 hour people to handle the pain. Unfortunately every 10mg of oxycodone is bundled with 325mg of acetaminaphen.
I really hope lobbying by Tylenol is eventually reversed and oxycodone and other opiates can be pressed into pills without acetaminaphen. It's ridiculous that I and others get close to poisoning our livers because of unnecessary bundling of drugs.
(FWIW I weight ~240 lbs)
- specialist 13y agoVirtual hug. I had my tonsils removed as an adult too. Not fun. I've been thru a lot. I thought "Ha, cake walk, no prob." Wrong.
- malandrew 13y agoThanks. It's pretty brutal. I've lost 25 lbs in 7 days already from it.