Your physiological perspective makes sense. I don't know a whole lot about posture and physiology. For my multiple 30" monitors, I keep them each about 3 feet

Your physiological perspective makes sense. I don't know a whole lot about posture and physiology. For my multiple 30" monitors, I keep them each about 3 feet from my eyes, more than an arm's length away. I suppose I have been blessed with fairly good eyesight because I don't zoom the view, instead keeping everything at 100% for most day-to-day usage. If I'm feeling like I want to relax, I'll zoom things in and recline a bit. I guess from my layperson perspective, I'd much rather move my eyes and head than deal with the contextual and organizational problems I would face by having to deal with a window stack. I'd rather not have to throw my left hand over to the tab key or have to reach for my mouse to shuffle some windows. I've used a multi-monitor configuration with the largest monitors I could afford for over a decade now and don't yet feel this has affected my physiology. But maybe I have a silent killer sneaking up on me? If you did need to zoom in to keep text legible for eyesight reasons, I'm not sure if the value would be as pronounced. But yes, I do think the clarity and crispness would be compelling enough for me. I've routinely said that if I rest my 300+ DPI cell phone on the surface of one of my Dell 30" U3011 monitors and look at both that and my monitor's display at the same distance (roughly 3 feet), the cell phone looks shockingly more legible and superior in just about every way. I so want to just tug at the edges of my cell phone's screen and make its screen big enough to fill my entire desk surface.