Running it well? No, with the one exception of the Mac Pro, which can supports 3 such monitors at once, but it has a GPU vastly more powerful than any Intel GPU

Running it well? No, with the one exception of the Mac Pro, which can supports 3 such monitors at once, but it has a GPU vastly more powerful than any Intel GPU inside the Macbooks. Iris Pro (5200+) is just now the starting point for running a 2.5k resolution (half of 4k) well enough. Anything less still struggles with 2.5k resolutions on a "full OS" like Mac OS/Windows/Linux. So if you want an Intel GPU running it, or anything at that level, you'll need to wait for a version that has 2x the performance of 5200, and then get a 4k monitor.