I've not tried running anything graphically. My previous machines for the past 7 or so years have been linux. I have my own bootstrap scripts for Python and R a

I've not tried running anything graphically. My previous machines for the past 7 or so years have been linux. I have my own bootstrap scripts for Python and R and some of the libs require RGtk2 and stuff, which couldn't really work on OS X without a lot of fiddling (but installing them on Ubuntu machines were a breeze). So when my bootstrap scripts failed, I ran them on a Vagrant based instance instead. Problem solved.