It depends on what kind of application you are developing:- Go Native if- 1. Need to access platform specific features example camera,gs,etc 2. Need performance

It depends on what kind of application you are developing:- Go Native if- 1. Need to access platform specific features example camera,gs,etc 2. Need performance intensive app 3. There is enough time for you to develop native app and can afford different native app developers (if planning to go cross platform) 4.You already know java/C#/Objective-C and it's a pain for you to learn HTML5 HTML5 if(you have some knowledge of HTML5/CSS and...):- 1. You need to build something quickly and cross platform 2. You can't afford different native app devs. 3. Performance is not that big an issue 4. You have/are a designer who can quickly conceptualize and build prototype using HTML5/CSS