To follow this up, I would also say the risk/reward ratio is not stacked in your favor. How happy and fulfilled would you be if you had a successful career but

To follow this up, I would also say the risk/reward ratio is not stacked in your favor. How happy and fulfilled would you be if you had a successful career but your health and personal relationships where in shambles? In my personal experience, nothing matters as much as those. I have been in a situation where I very nearly died, and let me tell you, you don't think about your career, or the money in situations like that. Those things simply are of no comfort.