My impression is there are a couple issues: - Methodology - If you're mining for answers, and then presenting only the statistically significant, you will stil

My impression is there are a couple issues: - Methodology - If you're mining for answers, and then presenting only the statistically significant, you will still find false positives on larger datasets, it will just take more work. - Reproduction - If false positives were more fiercely chased down, then this would force researchers to be more careful. There is improvement along these lines. Changing the p value is arbitrary, and may miss important results. I believe that encouraging reproduction of results, and reducing blind data mining is a better solution.