3 ms·
NAFLD is usually caused by obesity. However, it is also a common finding in those with ApoB defects. People with these defects have a curious phenotype: normal
by carbocation 13y ago
NAFLD is usually caused by obesity. However, it is also a common finding in those with ApoB defects. People with these defects have a curious phenotype: normal or even fantastic lipid levels but with NAFLD/NASH. Essentially, the defective ApoB doesn't get secreted from the liver so serum cholesterol levels look good, but the liver becomes fatty as it cannot export TG and cholesterol.
Certainly not trying to diagnose your familial disorder over the Internet, but taking a trip to a good lipid clinic might be something worth considering if you wanted to be aggressive in the pursuit of a diagnosis. (Which, again, might not be what I'm talking about above.)
- dhughes 13y ago> normal or even fantastic lipid levels At work a nurse comes in and we can get tested for high cholesterol, high blood pressure, diabetes. I go and each time even up until my NAFLD my numbers practically perfect. Maybe I do have some ApoB protein trouble. Although I doubt there is a lipid clinic anywhere in Canada for me to go to. Thanks anyway.
- carbocation 13y agoActually Canada has fantastic lipid clinics. (Disclosure: lipoproteins were the focus of my research and I collaborated with these folks.) Rob Hegele is a big name in lipids and his clinic is in Southwest Ontario, I believe.
- dhughes 13y agoI'm in the Maritimes and things are so well at my job so no go for travel, but maybe I'll mention it to my doctor. Thanks.