In that irrational assumes sentience, OK. The randomness being "we can't possibly predict all the elements that went into X happening" OK. But neither of those

In that irrational assumes sentience, OK. The randomness being "we can't possibly predict all the elements that went into X happening" OK. But neither of those matters in making an abstraction: the biological components didn't evolve outside of chemistry and physics. We can argue about how much detail would be needed, but is there really anything we can't abstract?