3 ms·

I didn't say that it targets different receptors. I said it targets them (i.e. the same receptors) differently. I failed to go into the details of how it target

I didn't say that it targets different receptors. I said it targets them (i.e. the same receptors) differently. I failed to go into the details of how it targets them differently (wasn't sure if that LOD was called for, or in good taste, considering that this is not a site about pharmacology or neurochemistry). I did see the wiki link... (I wouldn't have posted it if I hadn't.) Thank you for clarifying though! (BTW, I think that you meant somewhat not someone in your final sentence.)

nitrogen 13y ago
(wasn't sure if that LOD was called for, or in good taste, considering that this is not a site about pharmacology or neurochemistry). In my experience, detailed knowledge is always welcome on Hacker News, especially if it comes from another highly technical field outside software.
- kevgnulldev 13y ago
  Totally, my error for not adding value with some additional information in my last comment. Thank you. :) 1) some introductory material on receptor theory: http://en.wikipedia.org/wiki/Receptor_theory http://en.wikipedia.org/wiki/Receptor_theory Yes, I know Wikipedia, a more comprehensive intro to basic neuro is "Principles of Neural Science, 5th Ed" (http://www.mhprofessional.com/product.php?isbn=0071390111 http://www.mhprofessional.com/product.php?isbn=0071390111)... It's large book but the de facto standard. 2) a reference to some basic pharmacology with respect to opioid receptors that includes a summary discussion on receptor interactions (i.e. full agonists/antagonists/partial agonists): http://www.ncbi.nlm.nih.gov/books/NBK64236/ http://www.ncbi.nlm.nih.gov/books/NBK64236/ 3) some explanation per the specifics of the mu receptor (click on this only if you are truly thirsting for knowledge on the mu receptor): http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=319 http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objec... Have a nice night!

nitrogen 13y ago

(wasn't sure if that LOD was called for, or in good taste, considering that this is not a site about pharmacology or neurochemistry). In my experience, detailed knowledge is always welcome on Hacker News, especially if it comes from another highly technical field outside software.

kevgnulldev 13y ago
Totally, my error for not adding value with some additional information in my last comment. Thank you. :) 1) some introductory material on receptor theory: http://en.wikipedia.org/wiki/Receptor_theory http://en.wikipedia.org/wiki/Receptor_theory Yes, I know Wikipedia, a more comprehensive intro to basic neuro is "Principles of Neural Science, 5th Ed" (http://www.mhprofessional.com/product.php?isbn=0071390111 http://www.mhprofessional.com/product.php?isbn=0071390111)... It's large book but the de facto standard. 2) a reference to some basic pharmacology with respect to opioid receptors that includes a summary discussion on receptor interactions (i.e. full agonists/antagonists/partial agonists): http://www.ncbi.nlm.nih.gov/books/NBK64236/ http://www.ncbi.nlm.nih.gov/books/NBK64236/ 3) some explanation per the specifics of the mu receptor (click on this only if you are truly thirsting for knowledge on the mu receptor): http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=319 http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objec... Have a nice night!