That (CANBUS and RS485) works ok as long as everything agrees on what "ground" is. Using differential signaling (as both those standards do) does give you som

That (CANBUS and RS485) works ok as long as everything agrees on what "ground" is. Using differential signaling (as both those standards do) does give you some noise immunity and does help with the ground issue somewhat. The problem is that ground loops can easily generate 10's of volts at the highest impedance point, and there will be ground loops if you try to use this for "smart homeish" things. Most bus drivers and receivers aren't meant for voltages that high--many drivers/receivers have absolute maximum ratings only a few hundred millivolts below ground. Isolating everything isn't a conceptually difficult thing to do, but you'll spend just as much on optoisolators as you would have on ethernet magnetics.