5 ms·
> No. What you can take away from this is 'while no one doubts that at 100μg and higher one gets dramatic psychedelic effects, the suggestions that at tiny dose
by munchhausen 13y ago
> No. What you can take away from this is 'while no one doubts that at 100μg and higher one gets dramatic psychedelic effects, the suggestions that at tiny doses like 10μg there are non-psychedelic genericly positive effects, may not be true'. Don't confuse your hypotheses here.
What?? No, you can't take that away. In fact, what GP said still makes a lot more sense. 10ug didn't work for you, thus the dose was too low. Have you tried 15? 20? 30? It would almost certainly be sub-threshold when it comes to the psychedelia (unless you are a true freak of nature), but, who knows, maybe you would get an amazing nootropic effect!
Why did you decide to abort your experiment after trying only an arbitrary dose of 10ug?
- gwern 13y ago> Have you tried 15? 20? 30? It would almost certainly be sub-threshold when it comes to the psychedelia (unless you are a true freak of nature), but, who knows, maybe you would get an amazing nootropic effect! What? Dose-response curves do not work that way. They do not look like binary circuits where at 10mcg they do absolutely nothing and then at 15mcg go to the moon. They look like curves. If 15 mcg was better than 12, then I should have observed something like a medium effect. If 20mcg was better than 12, I should have observed something like a small-medium effect. If 30mcg was best, I should have seen signs of a small effect, possibly not statistically-significant, but clear point-value shifts. I observed none of that. > Why did you decide to abort your experiment after trying only an arbitrary dose of 10ug? It was closer to 12mcg, I did not 'abort' the experiment but carried it out to completion exactly as I had planned, and it was not arbitrary but close to the middle of the reasonable range of 5-30mcg.