Here's a starting point to summarize thoughts on that question from some of the better known researchers involved in human studies. http://impactaging.com/pape

Here's a starting point to summarize thoughts on that question from some of the better known researchers involved in human studies. http://impactaging.com/papers/v5/n7/full/100581.html http://impactaging.com/papers/v5/n7/full/100581.html "Whether or not CR will extend lifespan in humans is not yet known, but accumulating data indicate that moderate CR with adequate nutrition has a powerful protective effect against obesity, type 2 diabetes, inflammation, hypertension, cardiovascular disease and reduces metabolic risk factors associated with cancer." My summary of calorie restriction research is that it (a) produces similar-ish short term changes in metabolism and measures of health in mammals tried so far, and (b) is expected to have much smaller effects on life span in humans than in mice. The present consensus is that 5 years in humans would be on the high end, as I recall. The most interesting thing to resolve with certainty in this subfield is how the short-term measures can be so similar, how the expected reduction of age-related disease in humans can be so large, and yet the life expectancy outcome be so small. Should be interesting, in a post-facto sort of a way, as the time taken to figure that out will place us well into rejuvenation therapy territory, achieved through means that have nothing to do with CR or CR mimetics.