We've built StackOverflow with it. Is world's #55-ish network by traffic. So, yeah, it's certainly possible. On the other hand what do you mean by scale? There

We've built StackOverflow with it. Is world's #55-ish network by traffic. So, yeah, it's certainly possible. On the other hand what do you mean by scale? There is no way you can go internet scale with a "vanilla" framework. My advice? Use what you like, get the right people, don't be slave of a canned architecture or technology. You'll figure it out as you go.