Go with what the team is familiar with. If team is familar with MS stack, you can keep web layer in ASP.Net MVC/IIS/Windows. This will keep dev team very produc

Go with what the team is familiar with. If team is familar with MS stack, you can keep web layer in ASP.Net MVC/IIS/Windows. This will keep dev team very productive using Visual Studio/Windows combination and use open source products on linux in other layers like HA proxy for load balancer, varnish for reverse proxy, postgres/mongodb on linux for database/nosql. Stack overflow has had good success using similar approach.