Trivial in the sense that it would cost on the close order of $10 billion to figure it out, and the rewards would be in the $100s of trillions. Trivial also in

Trivial in the sense that it would cost on the close order of $10 billion to figure it out, and the rewards would be in the $100s of trillions. Trivial also in the sense that the general path to proofreading DNA is "obvious". Make a DNA segment that aligns upstream of the mutation. Glue a dicing enzyme to one end. This breaks the chromosome upstream of the mutation. Repeat for the downstream side, chopping out the mutation. Then incubate with the correct sequence and DNA repair enzymes. Voila, the mutation is repaired. This is nearly off the shelf. The not off the shelf part will be getting methylation and histone packing to come out right, otherwise you get subtle but appalling birth defects.