Ask HN: I Have 5 minutes to ask questions to a professor

In short, Tomorrow Ive been giving the opportunity to spend 5m alone with a very prominent researcher from Australia to ask him anything and everything. I want to ask him very basic questions to try to see how he thinks but if hit a wall. What questions would you ask? So far I've come up with the following: According to you... What is science: What has been the biggest failure during your scientific career: Where will the next paradigm shift be: How could science be improved: Is sciene worth pursuing as a career: Any help would be appreciated.