There's probably a bunch of different ways to do this, but I just use virtualenv + pip still. Here's some documentation on Django (as an example): https://docs

There's probably a bunch of different ways to do this, but I just use virtualenv + pip still. Here's some documentation on Django (as an example): https://docs.djangoproject.com/en/dev/howto/deployment/wsgi/modwsgi/#using-a-virtualenv https://docs.djangoproject.com/en/dev/howto/deployment/wsgi/... I think a more interesting question is not around the python side of things, but the infrastructure. Do you compile all your infra tools from source or do you use the system packages? Like, if you want to use RabbitMQ, if debian/Ubuntu provides it, would you use that or grab the source? I personally prefer to use the debian/ubuntu ones in these cases unless they are horribly outdated, which isn't generally the case. I can understand, however, if someone thinks this is a terrible idea.