Have you considered rewriting MySQL in Go? jk. What is the real nature of the queries, what kind of caching is being used? MySQL should not really get hit that

Have you considered rewriting MySQL in Go? jk. What is the real nature of the queries, what kind of caching is being used? MySQL should not really get hit that often if you have 150GB of data and a site, unless it's not getting content but running some sort of deep processing. In such a case MySQL seems like the wrong tool for the job.